| Player | Score | Balls | 4s | 6s | Opponent | Venue | Date |
|---|---|---|---|---|---|---|---|
| Wiaan Mulder | 367* | 334 | 49 | 4 | Zimbabwe | Queens Sports Club, Bulawayo | |
| Hashim Amla | 311* | 529 | 35 | 0 | England | Kennington Oval | |
| AB de Villiers | 278* | 418 | 23 | 6 | Pakistan | Sheikh Zayed Stadium | |
| Graeme Smith | 277 | 373 | 35 | 0 | England | Edgbaston, Birmingham | |
| Ryan Rickelton | 259 | 343 | 29 | 3 | Pakistan | Newlands, Cape Town | |
| Hashim Amla | 253* | 473 | 22 | 0 | India | Vidarbha Cricket Association Stadium, Jamtha | |
| Graeme Smith | 234 | 388 | 16 | 0 | Pakistan | Dubai International Cricket Stadium | |
| Graeme Smith | 232 | 277 | 33 | 1 | Bangladesh | Chittagong Divisional Stadium | |
| Herschelle Gibbs | 228 | 240 | 29 | 6 | Pakistan | Newlands, Cape Town | |
| Neil McKenzie | 226 | 388 | 28 | 3 | Bangladesh | Chittagong Divisional Stadium | |
| Jacques Kallis | 224 | 325 | 31 | 1 | Sri Lanka | Newlands | |
| AB de Villiers | 217* | 333 | 18 | 2 | India | Sardar Patel Stadium, Motera | |
| Hashim Amla | 208 | 371 | 22 | 0 | West Indies | SuperSport Park | |
| Jacques Kallis | 201* | 270 | 15 | 5 | India | SuperSport Park | |
| Hashim Amla | 201 | 477 | 27 | 0 | England | Newlands | |
| Faf du Plessis | 199 | 276 | 24 | 0 | Sri Lanka | SuperSport Park | |
| Dean Elgar | 199 | 388 | 15 | 3 | Bangladesh | Senwes Park | |
| Hashim Amla | 196 | 221 | 21 | 0 | Australia | Western Australia Cricket Association Ground | |
| Jacques Kallis | 186 | 262 | 25 | 3 | New Zealand | The Wanderers Stadium | |
| Dean Elgar | 185 | 287 | 28 | 0 | India | SuperSport Park, Centurion | |
| Herschelle Gibbs | 183 | 258 | 35 | 1 | England | Kennington Oval, London | |
| Graeme Smith | 183 | 273 | 25 | 0 | England | Newlands | |
| Jacques Kallis | 182* | 326 | 23 | 1 | England | Kennington Oval | |
| Alviro Petersen | 182 | 365 | 23 | 0 | England | Headingley | |
| Herschelle Gibbs | 179 | 236 | 29 | 1 | England | Edgbaston, Birmingham |